Ndị na-eme nchọpụta sitere na Ngalaba Mechanical na Aerospace Engineering (MAE) nke Herbert Wertheim School of Engineering ewepụtala ụdị akpụkpọ anụ hemodialysis ọhụrụ nke graphene oxide (GO), nke bụ ihe dị n'ụdị monoatomic.A na-atụ anya na ọ ga-eji ndidi gbanwee ọgwụgwọ dialysis akụrụ kpamkpam.Ọganihu a na-enye ohere ijikọ dialyzer microchip na akpụkpọ onye ọrịa.Na-arụ ọrụ n'okpuru nrụgide akwara, ọ ga-ewepụ mgbapụta ọbara na sekit ọbara extracorporeal, na-ekwe ka dialysis dị mma na nkasi obi nke ụlọ gị.E jiri ya tụnyere akpụkpọ anụ polymer dị ugbu a, njedebe nke akpụkpọ ahụ bụ iwu abụọ dị elu nke ukwuu, nwere ndakọrịta ọbara, ọ dịghịkwa mfe dị ka ọkpụkpụ polymer.
Prọfesọ Knox T. Millsaps nke MAE na onye na-eme nchọpụta na-eduzi ọrụ akpụkpọ ahụ Saeed Moghaddam na ndị otu ya emepụtala usoro ọhụrụ nke gụnyere nchịkọta onwe ya na njikarịcha nke anụ ahụ na kemịkal nke GO nanoplatelets.Usoro a na-atụgharị naanị ọkwa 3 GO ka ọ bụrụ mgbakọ nanosheet ahaziri nke ọma, si otú a na-enweta ikike dị elu na nhọrọ nhọrọ."Site n'ịmepụta akpụkpọ ahụ nke na-eme ka ọ dịkwuo mfe karịa ihe nkesa ya, akpụkpọ anụ glomerular okpuru ulo (GBM) nke akụrụ, anyị egosipụtawo ike dị ukwuu nke nanomaterials, nanoengineering, na molecular mgbakọ onwe."Mogda Dr. Mu kwuru.
Ọmụmụ arụmọrụ akpụkpọ ahụ na ọnọdụ hemodialysis arụpụtala ihe na-agba ume nke ukwuu.Ọnụọgụ ọnụọgụ nke urea na cytochrome-c bụ 0.5 na 0.4, n'otu n'otu, nke zuru oke maka dialysis nwayọ nwayọ ogologo oge ma na-ejigide ihe karịrị 99% nke albumin;ọmụmụ banyere hemolysis, mmeju ịgbalite na coagulation egosila na ha dị ka ihe ndị dị na akpụkpọ ahụ dialysis ma ọ bụ karịa arụmọrụ nke akpụkpọ ahụ dialysis dị ugbu a.Ebipụtala nsonaazụ ọmụmụ a na Advanced Materials Interfaces (February 5, 2021) n'okpuru aha "Trilayer Interlinked Graphene Oxide Membrane maka Wearable Hemodialyzer".
Dr. Moghaddam kwuru, sị: "Anyị egosipụtala ihe pụrụ iche nke GO nanoplatelet gbakọtara onwe ya nyere iwu mosaic, nke na-eme ka mgbalị afọ iri na-aga n'ihu na mmepe nke membranes dabeere na graphene."Ọ bụ ikpo okwu bara uru nke nwere ike ịkwalite dialysis abalị na-eru ala n'ụlọ. "Dr. Moghaddam na-arụ ọrụ ugbu a na mmepe nke microchips na-eji akpụkpọ anụ GO ọhụrụ, nke ga-eme ka nchọpụta dịkwuo nso na eziokwu nke ịnye ngwaọrụ hemodialysis wearable maka ndị ọrịa akụrụ.
Akwụkwọ akụkọ Nature (March 2020) kwuru, sị: “Òtù Ahụ́ Ike Ụwa na-eme atụmatụ na ihe dị ka nde mmadụ 1.2 na-anwụ n’ihi ọdịda akụrụ kwa afọ n’ụwa nile [na ọrịa akụrụ na-akwụsị ọgwụgwụ (ESRD) bụ n’ihi ọrịa shuga na ọbara mgbali elu]….Dialysis Nchikota nke njedebe bara uru nke teknụzụ na oke ego pụtakwara na ihe na-erughị ọkara nke ndị chọrọ ọgwụgwọ nwere ike ịnweta ya. "Ngwa ndị a na-eyi obere obere nke dabara adaba bụ ngwọta akụ na ụba iji bulie ọnụego nlanarị, ọkachasị na mmepe China.Dr. Moghaddam kwuru, "Mkpụrụkpụ anyị bụ isi ihe dị n'ime obere usoro wearable, nke nwere ike imepụtaghachi ọrụ nzacha nke akụrụ, na-eme ka ntụsara ahụ dịkwuo mma na ego zuru ụwa ọnụ."
"Ọganihu ndị dị ukwuu na ọgwụgwọ ndị ọrịa nwere hemodialysis na ọdịda akụrụ na-ejedebe site na teknụzụ akpụkpọ anụ.Teknụzụ Membrane enwebeghị ọganihu dị ukwuu n'ime iri afọ ole na ole gara aga.Ọganihu dị mkpa nke teknụzụ akpụkpọ anụ chọrọ mmelite nke dialysis gbasara akụrụ.Ngwa ndị nwere ike ịfefe nke ukwuu na nke na-ahọrọ, dị ka akpụkpọ anụ graphene oxide nke dị oke mkpa nke mepụtara ebe a, nwere ike ịgbanwe ihe atụ.Membrane dị nro dị nro nwere ike ọ bụghị naanị ịghọta dialyzers dị ntakịrị, kamakwa ezigbo ngwaọrụ mkpanaka na wearable, si otú ahụ na-eme ka ndụ ndụ dịkwuo mma na amụma onye ọrịa. "James L. McGrath kwuru na ya bụ prọfesọ nke injinia biomedical na Mahadum Rochester na onye na-emepụta ihe ọhụrụ teknụzụ silicon akpụkpọ anụ maka ngwa dị iche iche nke ndu (Nature, 2007).
Ụlọ ọrụ National Institute of Biomedical Imaging na Bioengineering (NIBIB) kwadoro nyocha a n'okpuru Ụlọ Ọrụ Na-ahụ Maka Ahụ Ike Mba.Dr. Moghaddam otu na-agụnye Dr. Richard P. Rode, postdoctoral ibe na UF MAE, Dr. Thomas R. Gaborski (onye na-eme nchọpụta onye isi), Daniel Ornt, MD (onye na-eme nchọpụta), na Henry C nke Ngalaba Biomedical. Injinia, Rochester Institute of Technology.Dr. Chung na Hayley N. Miller.
Dr. Moghaddam bụ onye so na UF Interdisciplinary Microsystems Group na-eduga Nanostructured Energy Systems Laboratory (NESLabs), onye ozi bụ imeziwanye ihe ọmụma larịị nke nanoengineering nke functional porous owuwu na micro/nanoscale nnyefe physics.Ọ na-achịkọta ọtụtụ ọzụzụ nke injinịa na sayensị iji ghọta nke ọma physics nke nnyefe micro/nano na ịzụlite usoro ọgbọ na sistemụ na-arụ ọrụ dị elu na arụmọrụ dị elu.
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